| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 |
| 1 | 10/09/25 | 6:00PM | New York Rangers | Buffalo Sabres | 4-0 (L) | 0-1-0 | 0-1-0 | 0-0-0 | 0-1-0 |
| 2 | 10/11/25 | 6:00PM | Buffalo Sabres | Boston Bruins | 1-3 (L) | 0-2-0 | 0-1-0 | 0-1-0 | 0-2-0 |
| 3 | 10/13/25 | 11:30AM | Colorado Avalanche | Buffalo Sabres | 3-1 (L) | 0-3-0 | 0-2-0 | 0-1-0 | 0-3-0 |
| 4 | 10/15/25 | 6:00PM | Ottawa Senators | Buffalo Sabres | 4-8 (W) | 1-3-0 | 1-2-0 | 0-1-0 | 1-3-0 |
| 5 | 10/18/25 | 12:00PM | Florida Panthers | Buffalo Sabres | 0-3 (W) | 2-3-0 | 2-2-0 | 0-1-0 | 2-3-0 |
| 6 | 10/20/25 | 6:30PM | Buffalo Sabres | Montreal Canadiens | 2-4 (L) | 2-4-0 | 2-2-0 | 0-2-0 | 2-4-0 |
| 7 | 10/22/25 | 6:30PM | Detroit Red Wings | Buffalo Sabres | 2-4 (W) | 3-4-0 | 3-2-0 | 0-2-0 | 3-4-0 |
| 8 | 10/24/25 | 6:00PM | Toronto Maple Leafs | Buffalo Sabres | 3-5 (W) | 4-4-0 | 4-2-0 | 0-2-0 | 4-4-0 |
| 9 | 10/25/25 | 4:00PM | Buffalo Sabres | Toronto Maple Leafs | 3-4 (OTL) | 4-4-1 | 4-2-0 | 0-2-1 | 4-4-1 |
| 10 | 10/28/25 | 6:45PM | Columbus Blue Jackets | Buffalo Sabres | 4-3 (OTL) | 4-4-2 | 4-2-1 | 0-2-1 | 4-4-2 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 11 | 10/30/25 | 6:00PM | Buffalo Sabres | Boston Bruins | 3-4 (OTL) | 4-4-3 | 4-2-1 | 0-2-2 | 4-3-3 |
| 12 | 11/01/25 | 6:00PM | Washington Capitals | Buffalo Sabres | 3-4 (SOW) | 5-4-3 | 5-2-1 | 0-2-2 | 5-2-3 |
| 13 | 11/04/25 | 7:00PM | Utah Hockey Club | Buffalo Sabres | 2-1 (OTL) | 5-4-4 | 5-2-2 | 0-2-2 | 5-1-4 |
| 14 | 11/06/25 | 7:00PM | St. Louis Blues | Buffalo Sabres | 3-0 (L) | 5-5-4 | 5-3-2 | 0-2-2 | 4-2-4 |
| 15 | 11/08/25 | 7:00PM | Buffalo Sabres | Carolina Hurricanes | 3-6 (L) | 5-6-4 | 5-3-2 | 0-3-2 | 3-3-4 |
| 16 | 11/12/25 | 9:00PM | Buffalo Sabres | Utah Hockey Club | 2-5 (L) | 5-7-4 | 5-3-2 | 0-4-2 | 3-3-4 |
| 17 | 11/13/25 | 9:00PM | Buffalo Sabres | Colorado Avalanche | 3-6 (L) | 5-8-4 | 5-3-2 | 0-5-2 | 2-4-4 |
| 18 | 11/15/25 | 7:00PM | Buffalo Sabres | Detroit Red Wings | 5-4 (OTW) | 6-8-4 | 5-3-2 | 1-5-2 | 2-4-4 |
| 19 | 11/17/25 | 7:00PM | Edmonton Oilers | Buffalo Sabres | 1-5 (W) | 7-8-4 | 6-3-2 | 1-5-2 | 3-4-3 |
| 20 | 11/19/25 | 7:30PM | Calgary Flames | Buffalo Sabres | 6-2 (L) | 7-9-4 | 6-4-2 | 1-5-2 | 3-5-2 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 21 | 11/21/25 | 7:00PM | Chicago Blackhawks | Buffalo Sabres | 3-9 (W) | 8-9-4 | 7-4-2 | 1-5-2 | 4-5-1 |
| 22 | 11/23/25 | 1:00PM | Carolina Hurricanes | Buffalo Sabres | 1-4 (W) | 9-9-4 | 8-4-2 | 1-5-2 | 4-5-1 |
| 23 | 11/26/25 | 7:00PM | Buffalo Sabres | Pittsburgh Penguins | 2-4 (L) | 9-10-4 | 8-4-2 | 1-6-2 | 4-6-0 |
| 24 | 11/28/25 | 4:00PM | New Jersey Devils | Buffalo Sabres | 5-0 (L) | 9-11-4 | 8-5-2 | 1-6-2 | 4-6-0 |
| 25 | 11/29/25 | 8:00PM | Buffalo Sabres | Minnesota Wild | 3-2 (SOW) | 10-11-4 | 8-5-2 | 2-6-2 | 5-5-0 |
| 26 | 12/01/25 | 7:30PM | Winnipeg Jets | Buffalo Sabres | 1-5 (W) | 11-11-4 | 9-5-2 | 2-6-2 | 6-4-0 |
| 27 | 12/03/25 | 7:30PM | Buffalo Sabres | Philadelphia Flyers | 2-5 (L) | 11-12-4 | 9-5-2 | 2-7-2 | 6-4-0 |
| 28 | 12/05/25 | 7:00PM | Buffalo Sabres | Winnipeg Jets | 1-4 (L) | 11-13-4 | 9-5-2 | 2-8-2 | 5-5-0 |
| 29 | 12/08/25 | 9:00PM | Buffalo Sabres | Calgary Flames | 4-7 (L) | 11-14-4 | 9-5-2 | 2-9-2 | 4-6-0 |
| 30 | 12/09/25 | 9:00PM | Buffalo Sabres | Edmonton Oilers | 4-3 (OTW) | 12-14-4 | 9-5-2 | 3-9-2 | 5-5-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 31 | 12/11/25 | 10:00PM | Buffalo Sabres | Vancouver Canucks | 3-2 (W) | 13-14-4 | 9-5-2 | 4-9-2 | 5-5-0 |
| 32 | 12/14/25 | 8:00PM | Buffalo Sabres | Seattle Kraken | 3-1 (W) | 14-14-4 | 9-5-2 | 5-9-2 | 5-5-0 |
| 33 | 12/18/25 | 7:30PM | Philadelphia Flyers | Buffalo Sabres | 3-5 (W) | 15-14-4 | 10-5-2 | 5-9-2 | 6-4-0 |
| 34 | 12/20/25 | 5:00PM | New York Islanders | Buffalo Sabres | 2-3 (SOW) | 16-14-4 | 11-5-2 | 5-9-2 | 7-3-0 |
| 35 | 12/21/25 | 7:00PM | Buffalo Sabres | New Jersey Devils | 3-1 (W) | 17-14-4 | 11-5-2 | 6-9-2 | 7-3-0 |
| 36 | 12/23/25 | 7:00PM | Buffalo Sabres | Ottawa Senators | 3-2 (OTW) | 18-14-4 | 11-5-2 | 7-9-2 | 7-3-0 |
| 37 | 12/27/25 | 7:00PM | Boston Bruins | Buffalo Sabres | 1-4 (W) | 19-14-4 | 12-5-2 | 7-9-2 | 8-2-0 |
| 38 | 12/29/25 | 8:00PM | Buffalo Sabres | St. Louis Blues | 4-2 (W) | 20-14-4 | 12-5-2 | 8-9-2 | 9-1-0 |
| 39 | 12/31/25 | 8:00PM | Buffalo Sabres | Dallas Stars | 4-1 (W) | 21-14-4 | 12-5-2 | 9-9-2 | 10-0-0 |
| 40 | 01/03/26 | 3:00PM | Buffalo Sabres | Columbus Blue Jackets | 1-5 (L) | 21-15-4 | 12-5-2 | 9-10-2 | 9-1-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 41 | 01/06/26 | 7:00PM | Vancouver Canucks | Buffalo Sabres | 3-5 (W) | 22-15-4 | 13-5-2 | 9-10-2 | 9-1-0 |
| 42 | 01/08/26 | 7:00PM | Buffalo Sabres | New York Rangers | Preview | ||||
| 43 | 01/10/26 | 7:00PM | Anaheim Ducks | Buffalo Sabres | Preview | ||||
| 44 | 01/12/26 | 7:00PM | Florida Panthers | Buffalo Sabres | Preview | ||||
| 45 | 01/14/26 | 7:30PM | Philadelphia Flyers | Buffalo Sabres | Preview | ||||
| 46 | 01/15/26 | 7:00PM | Montreal Canadiens | Buffalo Sabres | Preview | ||||
| 47 | 01/17/26 | 12:30PM | Minnesota Wild | Buffalo Sabres | Preview | ||||
| 48 | 01/19/26 | Buffalo Sabres | Carolina Hurricanes | Preview | |||||
| 49 | 01/20/26 | 8:00PM | Buffalo Sabres | Nashville Predators | Preview | ||||
| 50 | 01/22/26 | 7:00PM | Buffalo Sabres | Montreal Canadiens | Preview | ||||
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 51 | 01/24/26 | 1:00PM | Buffalo Sabres | New York Islanders | Preview |
| 52 | 01/27/26 | 7:00PM | Buffalo Sabres | Toronto Maple Leafs | Preview | ||||
| 53 | 01/29/26 | 7:00PM | Los Angeles Kings | Buffalo Sabres | Preview | ||||
| 54 | 01/31/26 | 7:00PM | Montreal Canadiens | Buffalo Sabres | Preview | ||||
| 55 | 02/02/26 | 7:00PM | Buffalo Sabres | Florida Panthers | Preview | ||||
| 56 | 02/03/26 | 7:30PM | Buffalo Sabres | Tampa Bay Lightning | Preview | ||||
| 57 | 02/05/26 | 7:00PM | Pittsburgh Penguins | Buffalo Sabres | Preview | ||||
| 58 | 02/25/26 | 7:00PM | Buffalo Sabres | New Jersey Devils | Preview | ||||
| 59 | 02/27/26 | 7:00PM | Buffalo Sabres | Florida Panthers | Preview | ||||
| 60 | 02/28/26 | 7:00PM | Buffalo Sabres | Tampa Bay Lightning | Preview | ||||
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 61 | 03/03/26 | 7:00PM | Vegas Golden Knights | Buffalo Sabres | Preview |
| 62 | 03/05/26 | 7:00PM | Buffalo Sabres | Pittsburgh Penguins | Preview | ||||
| 63 | 03/07/26 | 5:30PM | Nashville Predators | Buffalo Sabres | Preview | ||||
| 64 | 03/08/26 | 5:00PM | Tampa Bay Lightning | Buffalo Sabres | Preview | ||||
| 65 | 03/10/26 | 6:00PM | San Jose Sharks | Buffalo Sabres | Preview | ||||
| 66 | 03/12/26 | 6:00PM | Washington Capitals | Buffalo Sabres | Preview | ||||
| 67 | 03/14/26 | 6:00PM | Toronto Maple Leafs | Buffalo Sabres | Preview | ||||
| 68 | 03/17/26 | 9:00PM | Buffalo Sabres | Vegas Golden Knights | Preview | ||||
| 69 | 03/19/26 | 9:00PM | Buffalo Sabres | San Jose Sharks | Preview | ||||
| 70 | 03/21/26 | 3:00PM | Buffalo Sabres | Los Angeles Kings | Preview | ||||
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 71 | 03/22/26 | 7:00PM | Buffalo Sabres | Anaheim Ducks | Preview |
| 72 | 03/25/26 | 6:00PM | Boston Bruins | Buffalo Sabres | Preview | ||||
| 73 | 03/27/26 | 6:00PM | Detroit Red Wings | Buffalo Sabres | Preview | ||||
| 74 | 03/28/26 | 4:30PM | Seattle Kraken | Buffalo Sabres | Preview | ||||
| 75 | 03/31/26 | 6:00PM | New York Islanders | Buffalo Sabres | Preview | ||||
| 76 | 04/02/26 | 6:00PM | Buffalo Sabres | Ottawa Senators | Preview | ||||
| 77 | 04/04/26 | 6:00PM | Buffalo Sabres | Washington Capitals | Preview | ||||
| 78 | 04/06/26 | 6:00PM | Tampa Bay Lightning | Buffalo Sabres | Preview | ||||
| 79 | 04/08/26 | 6:00PM | Buffalo Sabres | New York Rangers | Preview | ||||
| 80 | 04/09/26 | 6:00PM | Columbus Blue Jackets | Buffalo Sabres | Preview | ||||
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 81 | 04/13/26 | 7:30PM | Buffalo Sabres | Chicago Blackhawks | Preview |
| 82 | 04/15/26 | 6:00PM | Dallas Stars | Buffalo Sabres | Preview | ||||