| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 |
| 1 | 10/08/24 | 7:00PM | Boston Bruins | Florida Panthers | 4-6 (L) | 0-1-0 | 0-0-0 | 0-1-0 | 0-1-0 |
| 2 | 10/10/24 | 7:00PM | Montreal Canadiens | Boston Bruins | 4-6 (W) | 1-1-0 | 1-0-0 | 0-1-0 | 1-1-0 |
| 3 | 10/12/24 | 1:00PM | Los Angeles Kings | Boston Bruins | 1-2 (OTW) | 2-1-0 | 2-0-0 | 0-1-0 | 2-1-0 |
| 4 | 10/14/24 | 1:00PM | Florida Panthers | Boston Bruins | 4-3 (L) | 2-2-0 | 2-1-0 | 0-1-0 | 2-2-0 |
| 5 | 10/16/24 | 9:30PM | Boston Bruins | Colorado Avalanche | 5-3 (W) | 3-2-0 | 2-1-0 | 1-1-0 | 3-2-0 |
| 6 | 10/19/24 | 9:00PM | Boston Bruins | Utah Hockey Club | 1-2 (OTL) | 3-2-1 | 2-1-0 | 1-1-1 | 3-2-1 |
| 7 | 10/22/24 | Boston Bruins | Nashville Predators | 0-4 (L) | 3-3-1 | 2-1-0 | 1-2-1 | 3-3-1 | |
| 8 | 10/24/24 | 7:00PM | Dallas Stars | Boston Bruins | 5-2 (L) | 3-4-1 | 2-2-0 | 1-2-1 | 3-4-1 |
| 9 | 10/26/24 | 7:00PM | Toronto Maple Leafs | Boston Bruins | 3-4 (OTW) | 4-4-1 | 3-2-0 | 1-2-1 | 4-4-1 |
| 10 | 10/29/24 | 7:00PM | Philadelphia Flyers | Boston Bruins | 2-0 (L) | 4-5-1 | 3-3-0 | 1-2-1 | 4-5-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 11 | 10/31/24 | 7:00PM | Boston Bruins | Carolina Hurricanes | 2-8 (L) | 4-6-1 | 3-3-0 | 1-3-1 | 4-5-1 |
| 12 | 11/02/24 | 1:00PM | Boston Bruins | Philadelphia Flyers | 3-0 (W) | 5-6-1 | 3-3-0 | 2-3-1 | 4-5-1 |
| 13 | 11/03/24 | 6:00PM | Seattle Kraken | Boston Bruins | 0-2 (W) | 6-6-1 | 4-3-0 | 2-3-1 | 4-5-1 |
| 14 | 11/05/24 | 8:00PM | Boston Bruins | Toronto Maple Leafs | 0-4 (L) | 6-7-1 | 4-3-0 | 2-4-1 | 4-5-1 |
| 15 | 11/07/24 | 8:00PM | Calgary Flames | Boston Bruins | 3-4 (OTW) | 7-7-1 | 5-3-0 | 2-4-1 | 4-5-1 |
| 16 | 11/09/24 | 8:00PM | Ottawa Senators | Boston Bruins | 3-2 (OTL) | 7-7-2 | 5-3-1 | 2-4-1 | 4-5-1 |
| 17 | 11/12/24 | 9:00PM | Boston Bruins | St. Louis Blues | 3-2 (W) | 8-7-2 | 5-3-1 | 3-4-1 | 5-4-1 |
| 18 | 11/14/24 | 9:00PM | Boston Bruins | Dallas Stars | 2-7 (L) | 8-8-2 | 5-3-1 | 3-5-1 | 5-4-1 |
| 19 | 11/16/24 | 2:00PM | St. Louis Blues | Boston Bruins | 3-2 (OTL) | 8-8-3 | 5-3-2 | 3-5-1 | 4-4-2 |
| 20 | 11/18/24 | 8:00PM | Columbus Blue Jackets | Boston Bruins | 5-1 (L) | 8-9-3 | 5-4-2 | 3-5-1 | 4-4-2 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 21 | 11/21/24 | 8:00PM | Utah Hockey Club | Boston Bruins | 0-1 (W) | 9-9-3 | 6-4-2 | 3-5-1 | 5-3-2 |
| 22 | 11/23/24 | 8:00PM | Boston Bruins | Detroit Red Wings | 2-1 (W) | 10-9-3 | 6-4-2 | 4-5-1 | 5-3-2 |
| 23 | 11/26/24 | 8:00PM | Vancouver Canucks | Boston Bruins | 2-0 (L) | 10-10-3 | 6-5-2 | 4-5-1 | 4-4-2 |
| 24 | 11/27/24 | 8:30PM | Boston Bruins | New York Islanders | 6-3 (W) | 11-10-3 | 6-5-2 | 5-5-1 | 5-3-2 |
| 25 | 11/29/24 | 7:30PM | Pittsburgh Penguins | Boston Bruins | 2-1 (L) | 11-11-3 | 6-6-2 | 5-5-1 | 4-4-2 |
| 26 | 12/01/24 | 4:00PM | Montreal Canadiens | Boston Bruins | 3-6 (W) | 12-11-3 | 7-6-2 | 5-5-1 | 5-4-1 |
| 27 | 12/03/24 | 8:00PM | Detroit Red Wings | Boston Bruins | 2-3 (OTW) | 13-11-3 | 8-6-2 | 5-5-1 | 5-4-1 |
| 28 | 12/04/24 | 8:30PM | Boston Bruins | Chicago Blackhawks | 4-2 (W) | 14-11-3 | 8-6-2 | 6-5-1 | 6-3-1 |
| 29 | 12/07/24 | 2:00PM | Philadelphia Flyers | Boston Bruins | 3-4 (OTW) | 15-11-3 | 9-6-2 | 6-5-1 | 7-3-0 |
| 30 | 12/10/24 | 9:00PM | Boston Bruins | Winnipeg Jets | 1-8 (L) | 15-12-3 | 9-6-2 | 6-6-1 | 7-3-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 31 | 12/12/24 | 11:00PM | Boston Bruins | Seattle Kraken | 1-5 (L) | 15-13-3 | 9-6-2 | 6-7-1 | 6-4-0 |
| 32 | 12/14/24 | 11:00PM | Boston Bruins | Vancouver Canucks | 5-1 (W) | 16-13-3 | 9-6-2 | 7-7-1 | 6-4-0 |
| 33 | 12/17/24 | 10:00PM | Boston Bruins | Calgary Flames | 4-3 (OTW) | 17-13-3 | 9-6-2 | 8-7-1 | 7-3-0 |
| 34 | 12/19/24 | 10:00PM | Boston Bruins | Edmonton Oilers | 2-3 (OTL) | 17-13-4 | 9-6-2 | 8-7-2 | 6-3-1 |
| 35 | 12/21/24 | 8:00PM | Buffalo Sabres | Boston Bruins | 1-3 (W) | 18-13-4 | 10-6-2 | 8-7-2 | 7-2-1 |
| 36 | 12/23/24 | 8:00PM | Washington Capitals | Boston Bruins | 1-4 (W) | 19-13-4 | 11-6-2 | 8-7-2 | 7-2-1 |
| 37 | 12/27/24 | 8:00PM | Boston Bruins | Columbus Blue Jackets | 2-6 (L) | 19-14-4 | 11-6-2 | 8-8-2 | 6-3-1 |
| 38 | 12/28/24 | 8:00PM | Columbus Blue Jackets | Boston Bruins | 0-4 (W) | 20-14-4 | 12-6-2 | 8-8-2 | 6-3-1 |
| 39 | 12/31/24 | 1:30PM | Boston Bruins | Washington Capitals | 1-3 (L) | 20-15-4 | 12-6-2 | 8-9-2 | 5-4-1 |
| 40 | 01/02/25 | 8:00PM | Boston Bruins | New York Rangers | 1-2 (L) | 20-16-4 | 12-6-2 | 8-10-2 | 5-4-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 41 | 01/04/25 | 8:00PM | Boston Bruins | Toronto Maple Leafs | 4-6 (L) | 20-17-4 | 12-6-2 | 8-11-2 | 5-4-1 |
| 42 | 01/05/25 | 7:00PM | New York Islanders | Boston Bruins | 5-4 (OTL) | 20-17-5 | 12-6-3 | 8-11-2 | 4-4-2 |
| 43 | 01/07/25 | 8:00PM | Edmonton Oilers | Boston Bruins | 4-0 (L) | 20-18-5 | 12-7-3 | 8-11-2 | 3-5-2 |
| 44 | 01/09/25 | 8:00PM | Boston Bruins | Tampa Bay Lightning | 1-4 (L) | 20-19-5 | 12-7-3 | 8-12-2 | 3-6-1 |
| 45 | 01/11/25 | 2:00PM | Boston Bruins | Florida Panthers | 4-3 (OTW) | 21-19-5 | 12-7-3 | 9-12-2 | 3-6-1 |
| 46 | 01/14/25 | 8:00PM | Tampa Bay Lightning | Boston Bruins | 2-6 (W) | 22-19-5 | 13-7-3 | 9-12-2 | 3-6-1 |
| 47 | 01/18/25 | 4:00PM | Boston Bruins | Ottawa Senators | 5-6 (SOL) | 22-19-6 | 13-7-3 | 9-12-3 | 3-5-2 |
| 48 | 01/20/25 | 2:00PM | San Jose Sharks | Boston Bruins | 3-6 (W) | 23-19-6 | 14-7-3 | 9-12-3 | 3-5-2 |
| 49 | 01/22/25 | 8:00PM | Boston Bruins | New Jersey Devils | 1-5 (L) | 23-20-6 | 14-7-3 | 9-13-3 | 3-5-2 |
| 50 | 01/23/25 | 8:00PM | Ottawa Senators | Boston Bruins | 0-2 (W) | 24-20-6 | 15-7-3 | 9-13-3 | 4-4-2 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 51 | 01/25/25 | 2:00PM | Colorado Avalanche | Boston Bruins | 1-3 (W) | 25-20-6 | 16-7-3 | 9-13-3 | 5-3-2 |
| 52 | 01/28/25 | 8:00PM | Boston Bruins | Buffalo Sabres | 2-7 (L) | 25-21-6 | 16-7-3 | 9-14-3 | 5-4-1 |
| 53 | 01/30/25 | 8:00PM | Winnipeg Jets | Boston Bruins | 6-2 (L) | 25-22-6 | 16-8-3 | 9-14-3 | 5-4-1 |
| 54 | 02/01/25 | New York Rangers | Boston Bruins | 3-6 (W) | 26-22-6 | 17-8-3 | 9-14-3 | 6-3-1 | |
| 55 | 02/04/25 | 8:00PM | Minnesota Wild | Boston Bruins | 0-3 (W) | 27-22-6 | 18-8-3 | 9-14-3 | 6-3-1 |
| 56 | 02/05/25 | 8:00PM | Boston Bruins | New York Rangers | 2-3 (L) | 27-23-6 | 18-8-3 | 9-15-3 | 5-4-1 |
| 57 | 02/08/25 | Vegas Golden Knights | Boston Bruins | 4-3 (L) | 27-24-6 | 18-9-3 | 9-15-3 | 5-5-0 | |
| 58 | 02/22/25 | 8:00PM | Anaheim Ducks | Boston Bruins | 3-2 (OTL) | 27-24-7 | 18-9-4 | 9-15-3 | 4-5-1 |
| 59 | 02/25/25 | 8:00PM | Toronto Maple Leafs | Boston Bruins | 5-4 (OTL) | 27-24-8 | 18-9-5 | 9-15-3 | 4-4-2 |
| 60 | 02/27/25 | 8:00PM | New York Islanders | Boston Bruins | 2-1 (L) | 27-25-8 | 18-10-5 | 9-15-3 | 3-5-2 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 61 | 03/01/25 | 4:00PM | Boston Bruins | Pittsburgh Penguins | 3-2 (W) | 28-25-8 | 18-10-5 | 10-15-3 | 3-5-2 |
| 62 | 03/02/25 | Boston Bruins | Minnesota Wild | 0-1 (L) | 28-26-8 | 18-10-5 | 10-16-3 | 3-5-2 | |
| 63 | 03/04/25 | 8:00PM | Nashville Predators | Boston Bruins | 6-3 (L) | 28-27-8 | 18-11-5 | 10-16-3 | 3-5-2 |
| 64 | 03/06/25 | 8:00PM | Boston Bruins | Carolina Hurricanes | 2-3 (L) | 28-28-8 | 18-11-5 | 10-17-3 | 2-6-2 |
| 65 | 03/08/25 | 4:00PM | Boston Bruins | Tampa Bay Lightning | 4-0 (W) | 29-28-8 | 18-11-5 | 11-17-3 | 2-6-2 |
| 66 | 03/11/25 | 7:00PM | Florida Panthers | Boston Bruins | 2-3 (W) | 30-28-8 | 19-11-5 | 11-17-3 | 3-5-2 |
| 67 | 03/13/25 | 7:00PM | Boston Bruins | Ottawa Senators | 3-6 (L) | 30-29-8 | 19-11-5 | 11-18-3 | 3-5-2 |
| 68 | 03/15/25 | 7:00PM | Tampa Bay Lightning | Boston Bruins | 6-2 (L) | 30-30-8 | 19-12-5 | 11-18-3 | 3-6-1 |
| 69 | 03/17/25 | 7:00PM | Buffalo Sabres | Boston Bruins | 3-2 (OTL) | 30-30-9 | 19-12-6 | 11-18-3 | 3-6-1 |
| 70 | 03/20/25 | 10:00PM | Boston Bruins | Vegas Golden Knights | 1-5 (L) | 30-31-9 | 19-12-6 | 11-19-3 | 3-6-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 71 | 03/22/25 | 10:30PM | Boston Bruins | San Jose Sharks | 1-3 (L) | 30-32-9 | 19-12-6 | 11-20-3 | 2-7-1 |
| 72 | 03/23/25 | 9:00PM | Boston Bruins | Los Angeles Kings | 2-7 (L) | 30-33-9 | 19-12-6 | 11-21-3 | 2-7-1 |
| 73 | 03/26/25 | 10:00PM | Boston Bruins | Anaheim Ducks | 2-6 (L) | 30-34-9 | 19-12-6 | 11-22-3 | 2-7-1 |
| 74 | 03/29/25 | 8:00PM | Boston Bruins | Detroit Red Wings | 1-2 (L) | 30-35-9 | 19-12-6 | 11-23-3 | 2-7-1 |
| 75 | 04/01/25 | 7:00PM | Washington Capitals | Boston Bruins | 4-3 (L) | 30-36-9 | 19-13-6 | 11-23-3 | 1-8-1 |
| 76 | 04/03/25 | 7:00PM | Boston Bruins | Montreal Canadiens | 1-4 (L) | 30-37-9 | 19-13-6 | 11-24-3 | 0-9-1 |
| 77 | 04/05/25 | 7:00PM | Carolina Hurricanes | Boston Bruins | 1-5 (W) | 31-37-9 | 20-13-6 | 11-24-3 | 1-8-1 |
| 78 | 04/06/25 | 6:00PM | Boston Bruins | Buffalo Sabres | 3-6 (L) | 31-38-9 | 20-13-6 | 11-25-3 | 1-8-1 |
| 79 | 04/08/25 | 7:00PM | Boston Bruins | New Jersey Devils | 7-2 (W) | 32-38-9 | 20-13-6 | 12-25-3 | 2-8-0 |
| 80 | 04/10/25 | 7:00PM | Chicago Blackhawks | Boston Bruins | 5-2 (L) | 32-39-9 | 20-14-6 | 12-25-3 | 2-8-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 81 | 04/13/25 | 3:30PM | Boston Bruins | Pittsburgh Penguins | 4-1 (W) | 33-39-9 | 20-14-6 | 13-25-3 | 3-7-0 |
| 82 | 04/15/25 | 7:00PM | New Jersey Devils | Boston Bruins | 5-4 (OTL) | 33-39-10 | 20-14-7 | 13-25-3 | 3-6-1 |