| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 |
| 1 | 10/09/24 | 7:00PM | Toronto Maple Leafs | Montreal Canadiens | 0-1 (L) | 0-1-0 | 0-0-0 | 0-1-0 | 0-1-0 |
| 2 | 10/10/24 | 7:00PM | Toronto Maple Leafs | New Jersey Devils | 4-2 (W) | 1-1-0 | 0-0-0 | 1-1-0 | 1-1-0 |
| 3 | 10/12/24 | 7:00PM | Pittsburgh Penguins | Toronto Maple Leafs | 2-4 (W) | 2-1-0 | 1-0-0 | 1-1-0 | 2-1-0 |
| 4 | 10/16/24 | 7:30PM | Los Angeles Kings | Toronto Maple Leafs | 2-6 (W) | 3-1-0 | 2-0-0 | 1-1-0 | 3-1-0 |
| 5 | 10/19/24 | 7:00PM | New York Rangers | Toronto Maple Leafs | 4-1 (L) | 3-2-0 | 2-1-0 | 1-1-0 | 3-2-0 |
| 6 | 10/21/24 | 7:30PM | Tampa Bay Lightning | Toronto Maple Leafs | 2-5 (W) | 4-2-0 | 3-1-0 | 1-1-0 | 4-2-0 |
| 7 | 10/22/24 | 7:30PM | Toronto Maple Leafs | Columbus Blue Jackets | 2-6 (L) | 4-3-0 | 3-1-0 | 1-2-0 | 4-3-0 |
| 8 | 10/24/24 | 7:00PM | St. Louis Blues | Toronto Maple Leafs | 5-1 (L) | 4-4-0 | 3-2-0 | 1-2-0 | 4-4-0 |
| 9 | 10/26/24 | 7:00PM | Toronto Maple Leafs | Boston Bruins | 3-4 (OTL) | 4-4-1 | 3-2-0 | 1-2-1 | 4-4-1 |
| 10 | 10/28/24 | 7:30PM | Toronto Maple Leafs | Winnipeg Jets | 6-4 (W) | 5-4-1 | 3-2-0 | 2-2-1 | 5-4-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 11 | 10/31/24 | 7:00PM | Seattle Kraken | Toronto Maple Leafs | 1-4 (W) | 6-4-1 | 4-2-0 | 2-2-1 | 6-3-1 |
| 12 | 11/02/24 | 7:00PM | Toronto Maple Leafs | St. Louis Blues | 2-4 (L) | 6-5-1 | 4-2-0 | 2-3-1 | 5-4-1 |
| 13 | 11/03/24 | 7:00PM | Toronto Maple Leafs | Minnesota Wild | 1-2 (OTL) | 6-5-2 | 4-2-0 | 2-3-2 | 4-4-2 |
| 14 | 11/05/24 | 8:00PM | Boston Bruins | Toronto Maple Leafs | 0-4 (W) | 7-5-2 | 5-2-0 | 2-3-2 | 4-4-2 |
| 15 | 11/08/24 | 8:00PM | Detroit Red Wings | Toronto Maple Leafs | 1-3 (W) | 8-5-2 | 6-2-0 | 2-3-2 | 5-3-2 |
| 16 | 11/09/24 | 8:00PM | Montreal Canadiens | Toronto Maple Leafs | 1-4 (W) | 9-5-2 | 7-2-0 | 2-3-2 | 5-3-2 |
| 17 | 11/12/24 | 8:00PM | Ottawa Senators | Toronto Maple Leafs | 3-0 (L) | 9-6-2 | 7-3-0 | 2-3-2 | 5-3-2 |
| 18 | 11/13/24 | 8:30PM | Toronto Maple Leafs | Washington Capitals | 4-3 (OTW) | 10-6-2 | 7-3-0 | 3-3-2 | 6-2-2 |
| 19 | 11/16/24 | 8:00PM | Edmonton Oilers | Toronto Maple Leafs | 3-4 (OTW) | 11-6-2 | 8-3-0 | 3-3-2 | 7-2-1 |
| 20 | 11/20/24 | 8:30PM | Vegas Golden Knights | Toronto Maple Leafs | 0-3 (W) | 12-6-2 | 9-3-0 | 3-3-2 | 7-2-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 21 | 11/24/24 | 8:00PM | Utah Hockey Club | Toronto Maple Leafs | 2-3 (W) | 13-6-2 | 10-3-0 | 3-3-2 | 7-2-1 |
| 22 | 11/27/24 | 8:30PM | Toronto Maple Leafs | Florida Panthers | 1-5 (L) | 13-7-2 | 10-3-0 | 3-4-2 | 7-2-1 |
| 23 | 11/30/24 | 8:00PM | Toronto Maple Leafs | Tampa Bay Lightning | 5-3 (W) | 14-7-2 | 10-3-0 | 4-4-2 | 8-2-0 |
| 24 | 12/02/24 | 8:30PM | Chicago Blackhawks | Toronto Maple Leafs | 1-4 (W) | 15-7-2 | 11-3-0 | 4-4-2 | 8-2-0 |
| 25 | 12/04/24 | 8:30PM | Nashville Predators | Toronto Maple Leafs | 2-3 (W) | 16-7-2 | 12-3-0 | 4-4-2 | 8-2-0 |
| 26 | 12/06/24 | 8:00PM | Washington Capitals | Toronto Maple Leafs | 3-1 (L) | 16-8-2 | 12-4-0 | 4-4-2 | 7-3-0 |
| 27 | 12/07/24 | 8:00PM | Toronto Maple Leafs | Pittsburgh Penguins | 2-5 (L) | 16-9-2 | 12-4-0 | 4-5-2 | 7-3-0 |
| 28 | 12/10/24 | 8:00PM | Toronto Maple Leafs | New Jersey Devils | 2-1 (OTW) | 17-9-2 | 12-4-0 | 5-5-2 | 7-3-0 |
| 29 | 12/12/24 | 8:00PM | Anaheim Ducks | Toronto Maple Leafs | 2-3 (W) | 18-9-2 | 13-4-0 | 5-5-2 | 7-3-0 |
| 30 | 12/14/24 | 8:00PM | Toronto Maple Leafs | Detroit Red Wings | 2-4 (L) | 18-10-2 | 13-4-0 | 5-6-2 | 6-4-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 31 | 12/15/24 | 6:00PM | Buffalo Sabres | Toronto Maple Leafs | 3-5 (W) | 19-10-2 | 14-4-0 | 5-6-2 | 6-4-0 |
| 32 | 12/18/24 | 8:30PM | Toronto Maple Leafs | Dallas Stars | 5-3 (W) | 20-10-2 | 14-4-0 | 6-6-2 | 7-3-0 |
| 33 | 12/20/24 | 8:00PM | Toronto Maple Leafs | Buffalo Sabres | 6-3 (W) | 21-10-2 | 14-4-0 | 7-6-2 | 7-3-0 |
| 34 | 12/21/24 | 8:00PM | New York Islanders | Toronto Maple Leafs | 6-3 (L) | 21-11-2 | 14-5-0 | 7-6-2 | 6-4-0 |
| 35 | 12/23/24 | 3:00PM | Winnipeg Jets | Toronto Maple Leafs | 5-2 (L) | 21-12-2 | 14-6-0 | 7-6-2 | 5-5-0 |
| 36 | 12/27/24 | 8:00PM | Toronto Maple Leafs | Detroit Red Wings | 5-2 (W) | 22-12-2 | 14-6-0 | 8-6-2 | 6-4-0 |
| 37 | 12/28/24 | 8:00PM | Washington Capitals | Toronto Maple Leafs | 5-2 (L) | 22-13-2 | 14-7-0 | 8-6-2 | 6-4-0 |
| 38 | 12/31/24 | 2:00PM | New York Islanders | Toronto Maple Leafs | 1-3 (W) | 23-13-2 | 15-7-0 | 8-6-2 | 6-4-0 |
| 39 | 01/02/25 | 8:30PM | Toronto Maple Leafs | New York Islanders | 2-1 (W) | 24-13-2 | 15-7-0 | 9-6-2 | 6-4-0 |
| 40 | 01/04/25 | 8:00PM | Boston Bruins | Toronto Maple Leafs | 4-6 (W) | 25-13-2 | 16-7-0 | 9-6-2 | 7-3-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 41 | 01/05/25 | 8:00PM | Philadelphia Flyers | Toronto Maple Leafs | 2-3 (OTW) | 26-13-2 | 17-7-0 | 9-6-2 | 7-3-0 |
| 42 | 01/07/25 | 8:30PM | Toronto Maple Leafs | Philadelphia Flyers | 3-2 (W) | 27-13-2 | 17-7-0 | 10-6-2 | 7-3-0 |
| 43 | 01/09/25 | 8:30PM | Toronto Maple Leafs | Carolina Hurricanes | 3-6 (L) | 27-14-2 | 17-7-0 | 10-7-2 | 6-4-0 |
| 44 | 01/11/25 | 8:00PM | Vancouver Canucks | Toronto Maple Leafs | 3-0 (L) | 27-15-2 | 17-8-0 | 10-7-2 | 6-4-0 |
| 45 | 01/14/25 | 8:00PM | Dallas Stars | Toronto Maple Leafs | 4-1 (L) | 27-16-2 | 17-9-0 | 10-7-2 | 6-4-0 |
| 46 | 01/16/25 | 8:00PM | New Jersey Devils | Toronto Maple Leafs | 3-4 (OTW) | 28-16-2 | 18-9-0 | 10-7-2 | 6-4-0 |
| 47 | 01/18/25 | 8:00PM | Toronto Maple Leafs | Montreal Canadiens | 7-3 (W) | 29-16-2 | 18-9-0 | 11-7-2 | 7-3-0 |
| 48 | 01/20/25 | 8:30PM | Tampa Bay Lightning | Toronto Maple Leafs | 3-5 (W) | 30-16-2 | 19-9-0 | 11-7-2 | 7-3-0 |
| 49 | 01/22/25 | 8:30PM | Columbus Blue Jackets | Toronto Maple Leafs | 5-1 (L) | 30-17-2 | 19-10-0 | 11-7-2 | 6-4-0 |
| 50 | 01/25/25 | 8:00PM | Toronto Maple Leafs | Ottawa Senators | 1-2 (L) | 30-18-2 | 19-10-0 | 11-8-2 | 5-5-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 51 | 01/29/25 | 8:00PM | Minnesota Wild | Toronto Maple Leafs | 3-1 (L) | 30-19-2 | 19-11-0 | 11-8-2 | 4-6-0 |
| 52 | 02/01/25 | 8:00PM | Toronto Maple Leafs | Edmonton Oilers | 4-3 (W) | 31-19-2 | 19-11-0 | 12-8-2 | 4-6-0 |
| 53 | 02/04/25 | 10:00PM | Toronto Maple Leafs | Calgary Flames | 6-3 (W) | 32-19-2 | 19-11-0 | 13-8-2 | 5-5-0 |
| 54 | 02/06/25 | 11:00PM | Toronto Maple Leafs | Seattle Kraken | 3-1 (W) | 33-19-2 | 19-11-0 | 14-8-2 | 6-4-0 |
| 55 | 02/08/25 | 8:00PM | Toronto Maple Leafs | Vancouver Canucks | 1-2 (L) | 33-20-2 | 19-11-0 | 14-9-2 | 6-4-0 |
| 56 | 02/22/25 | 8:00PM | Carolina Hurricanes | Toronto Maple Leafs | 3-6 (W) | 34-20-2 | 20-11-0 | 14-9-2 | 6-4-0 |
| 57 | 02/23/25 | 8:00PM | Toronto Maple Leafs | Chicago Blackhawks | 5-2 (W) | 35-20-2 | 20-11-0 | 15-9-2 | 6-4-0 |
| 58 | 02/25/25 | 8:00PM | Toronto Maple Leafs | Boston Bruins | 5-4 (OTW) | 36-20-2 | 20-11-0 | 16-9-2 | 6-4-0 |
| 59 | 02/28/25 | 8:00PM | Toronto Maple Leafs | New York Rangers | 3-2 (W) | 37-20-2 | 20-11-0 | 17-9-2 | 7-3-0 |
| 60 | 03/02/25 | 2:00PM | Toronto Maple Leafs | Pittsburgh Penguins | 6-5 (OTW) | 38-20-2 | 20-11-0 | 18-9-2 | 8-2-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 61 | 03/03/25 | 8:30PM | San Jose Sharks | Toronto Maple Leafs | 3-2 (SOL) | 38-20-3 | 20-11-1 | 18-9-2 | 8-1-1 |
| 62 | 03/05/25 | 11:00PM | Toronto Maple Leafs | Vegas Golden Knights | 2-5 (L) | 38-21-3 | 20-11-1 | 18-10-2 | 7-2-1 |
| 63 | 03/08/25 | 8:00PM | Toronto Maple Leafs | Colorado Avalanche | 4-7 (L) | 38-22-3 | 20-11-1 | 18-11-2 | 6-3-1 |
| 64 | 03/10/25 | 10:00PM | Toronto Maple Leafs | Utah Hockey Club | 4-3 (SOW) | 39-22-3 | 20-11-1 | 19-11-2 | 6-3-1 |
| 65 | 03/13/25 | 7:00PM | Florida Panthers | Toronto Maple Leafs | 3-2 (L) | 39-23-3 | 20-12-1 | 19-11-2 | 6-3-1 |
| 66 | 03/15/25 | 7:00PM | Ottawa Senators | Toronto Maple Leafs | 4-2 (L) | 39-24-3 | 20-13-1 | 19-11-2 | 5-4-1 |
| 67 | 03/17/25 | 7:30PM | Calgary Flames | Toronto Maple Leafs | 2-6 (W) | 40-24-3 | 21-13-1 | 19-11-2 | 5-4-1 |
| 68 | 03/19/25 | 7:00PM | Colorado Avalanche | Toronto Maple Leafs | 1-2 (W) | 41-24-3 | 22-13-1 | 19-11-2 | 5-4-1 |
| 69 | 03/20/25 | 7:00PM | Toronto Maple Leafs | New York Rangers | 4-3 (W) | 42-24-3 | 22-13-1 | 20-11-2 | 5-4-1 |
| 70 | 03/22/25 | 7:00PM | Toronto Maple Leafs | Nashville Predators | 2-5 (L) | 42-25-3 | 22-13-1 | 20-12-2 | 4-5-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 71 | 03/25/25 | 7:00PM | Philadelphia Flyers | Toronto Maple Leafs | 2-7 (W) | 43-25-3 | 23-13-1 | 20-12-2 | 5-5-0 |
| 72 | 03/27/25 | 10:30PM | Toronto Maple Leafs | San Jose Sharks | 5-6 (SOL) | 43-25-4 | 23-13-1 | 20-12-3 | 5-4-1 |
| 73 | 03/29/25 | 7:00PM | Toronto Maple Leafs | Los Angeles Kings | 3-1 (W) | 44-25-4 | 23-13-1 | 21-12-3 | 6-3-1 |
| 74 | 03/30/25 | 8:00PM | Toronto Maple Leafs | Anaheim Ducks | 3-2 (W) | 45-25-4 | 23-13-1 | 22-12-3 | 6-3-1 |
| 75 | 04/02/25 | 7:30PM | Florida Panthers | Toronto Maple Leafs | 2-3 (W) | 46-25-4 | 24-13-1 | 22-12-3 | 7-2-1 |
| 76 | 04/05/25 | 7:00PM | Columbus Blue Jackets | Toronto Maple Leafs | 0-5 (W) | 47-25-4 | 25-13-1 | 22-12-3 | 8-1-1 |
| 77 | 04/08/25 | 7:00PM | Toronto Maple Leafs | Florida Panthers | 1-3 (L) | 47-26-4 | 25-13-1 | 22-13-3 | 7-2-1 |
| 78 | 04/09/25 | 7:00PM | Toronto Maple Leafs | Tampa Bay Lightning | 4-3 (OTW) | 48-26-4 | 25-13-1 | 23-13-3 | 7-2-1 |
| 79 | 04/12/25 | 7:00PM | Montreal Canadiens | Toronto Maple Leafs | 0-1 (OTW) | 49-26-4 | 26-13-1 | 23-13-3 | 7-2-1 |
| 80 | 04/13/25 | 5:00PM | Toronto Maple Leafs | Carolina Hurricanes | 4-1 (W) | 50-26-4 | 26-13-1 | 24-13-3 | 8-1-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 81 | 04/15/25 | 7:00PM | Toronto Maple Leafs | Buffalo Sabres | 4-0 (W) | 51-26-4 | 26-13-1 | 25-13-3 | 8-1-1 |
| 82 | 04/17/25 | 7:00PM | Detroit Red Wings | Toronto Maple Leafs | 3-4 (OTW) | 52-26-4 | 27-13-1 | 25-13-3 | 9-1-0 |