| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 |
| 1 | 10/04/24 | 1:00PM | New Jersey Devils | Buffalo Sabres | 4-1 (L) | 0-1-0 | 0-1-0 | 0-0-0 | 0-1-0 |
| 2 | 10/05/24 | 10:00AM | Buffalo Sabres | New Jersey Devils | 1-3 (L) | 0-2-0 | 0-1-0 | 0-1-0 | 0-2-0 |
| 3 | 10/10/24 | 7:00PM | Los Angeles Kings | Buffalo Sabres | 3-1 (L) | 0-3-0 | 0-2-0 | 0-1-0 | 0-3-0 |
| 4 | 10/12/24 | 7:00PM | Florida Panthers | Buffalo Sabres | 2-5 (W) | 1-3-0 | 1-2-0 | 0-1-0 | 1-3-0 |
| 5 | 10/16/24 | 7:00PM | Buffalo Sabres | Pittsburgh Penguins | 5-6 (OTL) | 1-3-1 | 1-2-0 | 0-1-1 | 1-3-1 |
| 6 | 10/17/24 | 7:00PM | Buffalo Sabres | Columbus Blue Jackets | 4-6 (L) | 1-4-1 | 1-2-0 | 0-2-1 | 1-4-1 |
| 7 | 10/19/24 | 8:00PM | Buffalo Sabres | Chicago Blackhawks | 4-2 (W) | 2-4-1 | 1-2-0 | 1-2-1 | 2-4-1 |
| 8 | 10/22/24 | 7:00PM | Dallas Stars | Buffalo Sabres | 2-4 (W) | 3-4-1 | 2-2-0 | 1-2-1 | 3-4-1 |
| 9 | 10/26/24 | 1:00PM | Detroit Red Wings | Buffalo Sabres | 3-5 (W) | 4-4-1 | 3-2-0 | 1-2-1 | 4-4-1 |
| 10 | 10/28/24 | 7:00PM | Florida Panthers | Buffalo Sabres | 5-2 (L) | 4-5-1 | 3-3-0 | 1-2-1 | 4-5-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 11 | 11/01/24 | 7:00PM | New York Islanders | Buffalo Sabres | 4-3 (L) | 4-6-1 | 3-4-0 | 1-2-1 | 4-5-1 |
| 12 | 11/02/24 | 7:00PM | Buffalo Sabres | Detroit Red Wings | 1-2 (L) | 4-7-1 | 3-4-0 | 1-3-1 | 4-5-1 |
| 13 | 11/05/24 | 8:00PM | Ottawa Senators | Buffalo Sabres | 1-5 (W) | 5-7-1 | 4-4-0 | 1-3-1 | 5-4-1 |
| 14 | 11/07/24 | 8:00PM | Buffalo Sabres | New York Rangers | 6-1 (W) | 6-7-1 | 4-4-0 | 2-3-1 | 5-4-1 |
| 15 | 11/09/24 | 2:00PM | Calgary Flames | Buffalo Sabres | 2-3 (SOW) | 7-7-1 | 5-4-0 | 2-3-1 | 6-4-0 |
| 16 | 11/11/24 | 1:30PM | Montreal Canadiens | Buffalo Sabres | 7-5 (L) | 7-8-1 | 5-5-0 | 2-3-1 | 6-4-0 |
| 17 | 11/14/24 | 8:30PM | St. Louis Blues | Buffalo Sabres | 3-4 (OTW) | 8-8-1 | 6-5-0 | 2-3-1 | 6-4-0 |
| 18 | 11/16/24 | 8:00PM | Buffalo Sabres | Philadelphia Flyers | 2-5 (L) | 8-9-1 | 6-5-0 | 2-4-1 | 5-5-0 |
| 19 | 11/20/24 | 11:30PM | Buffalo Sabres | Los Angeles Kings | 1-0 (W) | 9-9-1 | 6-5-0 | 3-4-1 | 5-5-0 |
| 20 | 11/22/24 | 11:00PM | Buffalo Sabres | Anaheim Ducks | 3-2 (OTW) | 10-9-1 | 6-5-0 | 4-4-1 | 6-4-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 21 | 11/23/24 | 9:00PM | Buffalo Sabres | San Jose Sharks | 4-2 (W) | 11-9-1 | 6-5-0 | 5-4-1 | 7-3-0 |
| 22 | 11/27/24 | 8:00PM | Minnesota Wild | Buffalo Sabres | 1-0 (L) | 11-10-1 | 6-6-0 | 5-4-1 | 7-3-0 |
| 23 | 11/29/24 | 4:00PM | Vancouver Canucks | Buffalo Sabres | 4-3 (OTL) | 11-10-2 | 6-6-1 | 5-4-1 | 6-3-1 |
| 24 | 11/30/24 | 8:30PM | Buffalo Sabres | New York Islanders | 0-3 (L) | 11-11-2 | 6-6-1 | 5-5-1 | 5-4-1 |
| 25 | 12/03/24 | 8:00PM | Colorado Avalanche | Buffalo Sabres | 5-4 (L) | 11-12-2 | 6-7-1 | 5-5-1 | 4-5-1 |
| 26 | 12/05/24 | 8:00PM | Winnipeg Jets | Buffalo Sabres | 3-2 (OTL) | 11-12-3 | 6-7-2 | 5-5-1 | 4-4-2 |
| 27 | 12/07/24 | 2:00PM | Utah Hockey Club | Buffalo Sabres | 5-2 (L) | 11-13-3 | 6-8-2 | 5-5-1 | 3-5-2 |
| 28 | 12/09/24 | 8:00PM | Detroit Red Wings | Buffalo Sabres | 6-5 (SOL) | 11-13-4 | 6-8-3 | 5-5-1 | 3-4-3 |
| 29 | 12/11/24 | 8:00PM | New York Rangers | Buffalo Sabres | 3-2 (L) | 11-14-4 | 6-9-3 | 5-5-1 | 2-5-3 |
| 30 | 12/14/24 | 8:00PM | Buffalo Sabres | Washington Capitals | 2-4 (L) | 11-15-4 | 6-9-3 | 5-6-1 | 1-6-3 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 31 | 12/15/24 | 6:00PM | Buffalo Sabres | Toronto Maple Leafs | 3-5 (L) | 11-16-4 | 6-9-3 | 5-7-1 | 0-7-3 |
| 32 | 12/17/24 | 8:00PM | Buffalo Sabres | Montreal Canadiens | 1-6 (L) | 11-17-4 | 6-9-3 | 5-8-1 | 0-7-3 |
| 33 | 12/20/24 | 8:00PM | Toronto Maple Leafs | Buffalo Sabres | 6-3 (L) | 11-18-4 | 6-10-3 | 5-8-1 | 0-8-2 |
| 34 | 12/21/24 | 8:00PM | Buffalo Sabres | Boston Bruins | 1-3 (L) | 11-19-4 | 6-10-3 | 5-9-1 | 0-8-2 |
| 35 | 12/23/24 | 8:30PM | Buffalo Sabres | New York Islanders | 7-1 (W) | 12-19-4 | 6-10-3 | 6-9-1 | 1-7-2 |
| 36 | 12/27/24 | 8:00PM | Chicago Blackhawks | Buffalo Sabres | 2-6 (W) | 13-19-4 | 7-10-3 | 6-9-1 | 2-7-1 |
| 37 | 12/29/24 | 4:00PM | Buffalo Sabres | St. Louis Blues | 4-2 (W) | 14-19-4 | 7-10-3 | 7-9-1 | 3-6-1 |
| 38 | 12/31/24 | 9:00PM | Buffalo Sabres | Dallas Stars | 2-4 (L) | 14-20-4 | 7-10-3 | 7-10-1 | 3-7-0 |
| 39 | 01/02/25 | 10:00PM | Buffalo Sabres | Colorado Avalanche | 5-6 (OTL) | 14-20-5 | 7-10-3 | 7-10-2 | 3-6-1 |
| 40 | 01/04/25 | 11:00PM | Buffalo Sabres | Vegas Golden Knights | 1-3 (L) | 14-21-5 | 7-10-3 | 7-11-2 | 3-6-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 41 | 01/06/25 | 8:00PM | Washington Capitals | Buffalo Sabres | 3-4 (SOW) | 15-21-5 | 8-10-3 | 7-11-2 | 4-5-1 |
| 42 | 01/09/25 | 8:00PM | Buffalo Sabres | Ottawa Senators | 4-0 (W) | 16-21-5 | 8-10-3 | 8-11-2 | 5-4-1 |
| 43 | 01/11/25 | 5:00PM | Seattle Kraken | Buffalo Sabres | 6-2 (L) | 16-22-5 | 8-11-3 | 8-11-2 | 5-4-1 |
| 44 | 01/15/25 | 7:00PM | Carolina Hurricanes | Buffalo Sabres | 2-4 (W) | 17-22-5 | 9-11-3 | 8-11-2 | 6-3-1 |
| 45 | 01/17/25 | 8:00PM | Pittsburgh Penguins | Buffalo Sabres | 5-2 (L) | 17-23-5 | 9-12-3 | 8-11-2 | 5-4-1 |
| 46 | 01/20/25 | 5:00PM | Buffalo Sabres | Seattle Kraken | 4-6 (L) | 17-24-5 | 9-12-3 | 8-12-2 | 4-5-1 |
| 47 | 01/21/25 | 11:00PM | Buffalo Sabres | Vancouver Canucks | 3-2 (W) | 18-24-5 | 9-12-3 | 9-12-2 | 4-5-1 |
| 48 | 01/23/25 | 10:00PM | Buffalo Sabres | Calgary Flames | 2-5 (L) | 18-25-5 | 9-12-3 | 9-13-2 | 4-5-1 |
| 49 | 01/25/25 | 5:00PM | Buffalo Sabres | Edmonton Oilers | 2-3 (L) | 18-26-5 | 9-12-3 | 9-14-2 | 4-6-0 |
| 50 | 01/28/25 | 8:00PM | Boston Bruins | Buffalo Sabres | 2-7 (W) | 19-26-5 | 10-12-3 | 9-14-2 | 5-5-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 51 | 01/31/25 | 8:00PM | Nashville Predators | Buffalo Sabres | 3-4 (W) | 20-26-5 | 11-12-3 | 9-14-2 | 5-5-0 |
| 52 | 02/02/25 | 2:00PM | New Jersey Devils | Buffalo Sabres | 3-4 (W) | 21-26-5 | 12-12-3 | 9-14-2 | 5-5-0 |
| 53 | 02/04/25 | 8:00PM | Columbus Blue Jackets | Buffalo Sabres | 2-3 (W) | 22-26-5 | 13-12-3 | 9-14-2 | 6-4-0 |
| 54 | 02/08/25 | 9:00PM | Buffalo Sabres | Nashville Predators | 4-6 (L) | 22-27-5 | 13-12-3 | 9-15-2 | 5-5-0 |
| 55 | 02/22/25 | 6:30PM | New York Rangers | Buffalo Sabres | 2-8 (W) | 23-27-5 | 14-12-3 | 9-15-2 | 6-4-0 |
| 56 | 02/25/25 | 8:00PM | Anaheim Ducks | Buffalo Sabres | 2-3 (W) | 24-27-5 | 15-12-3 | 9-15-2 | 7-3-0 |
| 57 | 02/27/25 | 8:00PM | Buffalo Sabres | Carolina Hurricanes | 2-5 (L) | 24-28-5 | 15-12-3 | 9-16-2 | 6-4-0 |
| 58 | 03/01/25 | 8:00PM | Montreal Canadiens | Buffalo Sabres | 4-2 (L) | 24-29-5 | 15-13-3 | 9-16-2 | 6-4-0 |
| 59 | 03/03/25 | 8:00PM | Buffalo Sabres | Montreal Canadiens | 3-4 (OTL) | 24-29-6 | 15-13-3 | 9-16-3 | 6-3-1 |
| 60 | 03/04/25 | 8:00PM | San Jose Sharks | Buffalo Sabres | 6-2 (L) | 24-30-6 | 15-14-3 | 9-16-3 | 5-4-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 61 | 03/06/25 | 8:00PM | Buffalo Sabres | Tampa Bay Lightning | 5-6 (L) | 24-31-6 | 15-14-3 | 9-17-3 | 4-5-1 |
| 62 | 03/08/25 | 7:00PM | Buffalo Sabres | Florida Panthers | 0-4 (L) | 24-32-6 | 15-14-3 | 9-18-3 | 3-6-1 |
| 63 | 03/10/25 | 7:00PM | Edmonton Oilers | Buffalo Sabres | 2-3 (W) | 25-32-6 | 16-14-3 | 9-18-3 | 3-6-1 |
| 64 | 03/12/25 | 7:30PM | Buffalo Sabres | Detroit Red Wings | 3-7 (L) | 25-33-6 | 16-14-3 | 9-19-3 | 3-6-1 |
| 65 | 03/15/25 | 12:30PM | Vegas Golden Knights | Buffalo Sabres | 3-4 (SOW) | 26-33-6 | 17-14-3 | 9-19-3 | 3-6-1 |
| 66 | 03/17/25 | 7:00PM | Buffalo Sabres | Boston Bruins | 3-2 (OTW) | 27-33-6 | 17-14-3 | 10-19-3 | 3-6-1 |
| 67 | 03/20/25 | 9:00PM | Buffalo Sabres | Utah Hockey Club | 2-5 (L) | 27-34-6 | 17-14-3 | 10-20-3 | 3-6-1 |
| 68 | 03/22/25 | 2:00PM | Buffalo Sabres | Minnesota Wild | 1-4 (L) | 27-35-6 | 17-14-3 | 10-21-3 | 3-6-1 |
| 69 | 03/23/25 | 3:00PM | Buffalo Sabres | Winnipeg Jets | 5-3 (W) | 28-35-6 | 17-14-3 | 11-21-3 | 4-6-0 |
| 70 | 03/25/25 | 7:00PM | Ottawa Senators | Buffalo Sabres | 2-3 (W) | 29-35-6 | 18-14-3 | 11-21-3 | 5-5-0 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 71 | 03/27/25 | 7:00PM | Pittsburgh Penguins | Buffalo Sabres | 3-7 (W) | 30-35-6 | 19-14-3 | 11-21-3 | 6-4-0 |
| 72 | 03/29/25 | 1:00PM | Buffalo Sabres | Philadelphia Flyers | 4-7 (L) | 30-36-6 | 19-14-3 | 11-22-3 | 6-4-0 |
| 73 | 03/30/25 | 3:00PM | Buffalo Sabres | Washington Capitals | 8-5 (W) | 31-36-6 | 19-14-3 | 12-22-3 | 6-4-0 |
| 74 | 04/01/25 | 7:00PM | Buffalo Sabres | Ottawa Senators | 5-2 (W) | 32-36-6 | 19-14-3 | 13-22-3 | 7-3-0 |
| 75 | 04/05/25 | 7:00PM | Tampa Bay Lightning | Buffalo Sabres | 2-3 (SOW) | 33-36-6 | 20-14-3 | 13-22-3 | 7-3-0 |
| 76 | 04/06/25 | 6:00PM | Boston Bruins | Buffalo Sabres | 3-6 (W) | 34-36-6 | 21-14-3 | 13-22-3 | 7-3-0 |
| 77 | 04/08/25 | 7:00PM | Carolina Hurricanes | Buffalo Sabres | 0-3 (W) | 35-36-6 | 22-14-3 | 13-22-3 | 8-2-0 |
| 78 | 04/10/25 | 7:00PM | Buffalo Sabres | Columbus Blue Jackets | 2-3 (L) | 35-37-6 | 22-14-3 | 13-23-3 | 8-2-0 |
| 79 | 04/12/25 | 6:00PM | Buffalo Sabres | Florida Panthers | 2-3 (SOL) | 35-37-7 | 22-14-3 | 13-23-4 | 7-2-1 |
| 80 | 04/13/25 | 6:00PM | Buffalo Sabres | Tampa Bay Lightning | 4-7 (L) | 35-38-7 | 22-14-3 | 13-24-4 | 6-3-1 |
| Game # | Date | Time | Away | Home | Score | Record | Home | Away | Last 10 | 81 | 04/15/25 | 7:00PM | Toronto Maple Leafs | Buffalo Sabres | 4-0 (L) | 35-39-7 | 22-15-3 | 13-24-4 | 5-4-1 |
| 82 | 04/17/25 | 7:00PM | Philadelphia Flyers | Buffalo Sabres | 4-5 (W) | 36-39-7 | 23-15-3 | 13-24-4 | 6-3-1 |